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It also can inhibit ribonucleotide reductase, the enzyme responsible for DNA synthesis that contains a tyrosine radical

So in ALS, rather than driving pathology, the baseline microbiome might be trying to counteract it, and losing key microbes removes that brake on microglial activation

specifically, lycopene capsules and intralesional injected betamethasone were comparatively effective in increasing the mouth opening in patients at stage I, while betamethasone was more effective than lycopene in stage II, by contrast, lycopene was more potent than betamethasone in stage III

Admittedly, an early reduction in iron concentration in the context of a progressive neurodegenerative disease might seem counterintuitive